Acyclovir cream has the ability to treat all the effects of herpes such as shingles, cold sores, itching, redness, as well as rashes. You can use valtrex for shingles and you can also use Acyclovir for cold sores. For this you can opt for valtrex shingles. valtrex herpes is for the treatment of effects that are caused because of herpes. This medication also has certain side effects but if you have this drug under proper supervision of your doctor, you do not have to worry about the side effects.